Optimal counter-current exchange networks

Across mammalian species, solute exchange takes place in complex microvascular networks. In the human placenta, the primary exchange units are terminal villi that contain disordered networks of fetal capillaries and are surrounded externally by maternal blood. Here we show how the irregular internal structure of a terminal villus determines its exchange capacity for a wide range of solutes. Distilling geometric features into three scalar parameters, obtained from image analys...

One of the ways natural and synthetic systems regulate temperature is via circulating fluids through vasculatures embedded within their bodies. Because of the flexibility and availability of proven fabrication techniques, vascular-based thermal regulation is attractive for thin microvascular systems. Although preliminary designs and experiments demonstrate the feasibility of thermal modulation by pushing fluid through embedded micro-vasculatures, one has yet to optimize the p...

We present an asymptotic analysis of a mesoscale energy for bilayer membranes that has been introduced and analyzed in two space dimensions by the second and third author (Arch. Ration. Mech. Anal. 193, 2009). The energy is both non-local and non-convex. It combines a surface area and a Monge-Kantorovich-distance term, leading to a competition between preferences for maximally concentrated and maximally dispersed configurations. Here we extend key results of our previous anal...

In this paper, we investigate the physical mechanisms underlying one of the most efficient filtration devices: the kidney. Building on a minimal model of the Henle loop - the central part of the kidney filtration - we investigate theoretically the detailed out-of-equilibrium fluxes in this separation process in order to obtain absolute theoretical bounds for its efficiency in terms of separation ability and energy consumption. We demonstrate that this separation process opera...

For the problem of efficiently supplying material to a spatial region from a single source, we present a simple scaling argument based on branching network volume minimization that identifies limits to the scaling of sink density. We discuss implications for two fundamental and unresolved problems in organismal biology and geomorphology: how basal metabolism scales with body size for homeotherms and the scaling of drainage basin shape on eroding landscapes.

A plethora of computational models have been developed in recent decades to account for the morphogenesis of complex biological fluid networks, such as capillary beds. Contemporary adaptation models are based on optimization schemes where networks react and adapt toward given flow patterns. Doing so, a system reduces dissipation and network volume, thereby altering its final form. Yet, recent numeric studies on network morphogenesis, incorporating uptake of metabolites by the...

A method for density-based topology optimization of heat exchangers with two fluids is proposed. The goal of the optimization process is to maximize the heat transfer from one fluid to the other, under maximum pressure drop constraints for each of the fluid flows. A single design variable is used to describe the physical fields. The solid interface and the fluid domains are generated using an erosion-dilation based identification technique, which guarantees well-separated flu...

In recent years, new methods have been developed to synthesize complex porous and micro-structured geometry in a variety of ways. In this work, we take these approaches one step further and present these methods as an efficacious design paradigm. Specifically, complex micro-structure geometry can be synthesized while optimizing certain properties such as maximal heat exchange in heat exchangers, or minimal weight under stress specifications. By being able to adjust the geomet...

Salt transport in bulk electrolytes is limited by diffusion and convection, but in microstructures with charged surfaces (e.g. microfluidic devices, porous media, soils, or biological tissues) surface conduction and electro-osmotic flow also contribute to ionic fluxes. For small applied voltages, these effects lead to well known linear electrokinetic phenomena. In this paper, we predict some surprising nonlinear dynamics that can result from the competition between bulk and i...

We study a model of cell motility where the condition of optimal trade-off between performance and metabolic cost can be made precise. In this model a steadily crawling fragment is represented by a layer of active gel placed on a frictional surface and driven by contraction only. We find analytically the distribution of contractile elements (pullers) ensuring that the efficiency of self-propulsion is maximal. We then show that natural assumptions about advection and diffusion...