Multiscale fabrication of scalable biomimetic 3-D, integrated micro-nanochannels network in PDMS for solute exchange

The integration of a PDMS membrane within orthogonally placed PMMA microfluidic channels enables the pneumatic actuation of valves within bonded PMMA-PDMS-PMMA multilayer devices. Here, surface functionalization of PMMA substrates via acid catalyzed hydrolysis and air plasma corona treatment were investigated as possible techniques to permanently bond PMMA microfluidic channels to PDMS surfaces. FTIR and water contact angle analysis of functionalized PMMA substrates showed th...

A microfluidic device is constructed from PDMS with a single channel having a short section that is a thin flexible membrane, in order to investigate the complex fluid-structure interaction that arises between a flowing fluid and a deformable wall. Experimental measurements of membrane deformation and pressure drop are compared with predictions of two-dimensional and three-dimensional computational models which numerically solve the equations governing the elasticity of the m...

Biological systems have been theoretically predicted to support phononic topological wave-modes, similar to the ones existing in meta-materials. The existing methods to measure these modes, however cannot be applied to biological systems; new techniques have to be developed to accommodate phononic measurements in life science. Motivated by this perspective, we report a nanofluidic device for studying one microtubule at a time. Microchannels etched into fused-silica using reac...

Microfluidic chips provide unparalleled control over droplets and jets, which have advanced all natural sciences. However, microfluidic applications could be vastly expanded by increasing the per-channel throughput and directly exploiting the output of chips for rapid additive manufacturing. We unlock these features with in-air microfluidics, a new chip-free platform to manipulate microscale liquid streams in the air. By controlling the composition and in-air impact of liquid...

Microfluidics have emerged as a vital tool in various scientific and engineering applications, ranging from biomedical diagnostics to chemical analysis. However, conventional fabrication methods often necessitate costly equipment and limiting accessibility, thereby hindering widespread adoption. In response, this note presents a cost-effective approach for fabricating microfluidic channels using photolithographic methods, which circumvents the need for expensive instruments. ...

We report on the development of some process capabilities for a polymer-based, multi-layer microelectrofluidic platform, namely: the hot embossing process, metallization on polymer and polymer bonding. Hot embossing experiments were conducted to look at the effects of load applied, embossing temperature and embossing time on the fidelity of line arrays representing micro channels. The results revealed that the embossing temperature is a more sensitive parameter than the other...

Large-scale microfluidic microsystems with complex three-dimensional (3D) configurations are highly in demand by both fundamental research and industrial application, holding the potentials for fostering a wide range of innovative applications such as lab-on-a-chip and organ-on-a-chip as well as continuous-flow manufacturing of fine chemicals. However, freeform fabrication of such systems remains challenging for most of the current fabrication techniques in terms of fabricati...

Pumping fluids without an aid of an external power source are desirable in a number of applications ranging from a cooling of microelectronic circuits to Micro Total Analysis Systems (micro-TAS). Although, several microfluidic pumps exist, yet passive micropumps demonstrate better energy efficiency while providing a better control over a pumping rate and its operation. The fluid pumping rate and their easy maneuverability are critical in some applications; therefore, in the c...

Constructing precise micro-nano metal patterns on complex three-dimensional (3D) plastic parts allows the fabrication of functional devices for advanced applications. However, this patterning is currently expensive and requires complex processes with long manufacturing lead time. The present work demonstrates a process for the fabrication of micro-nano 3D metal-plastic composite structures with arbitrarily complex shapes. In this approach, a light-cured resin is modified to p...

Stereolithographic 3D-printing (SLA) permits facile fabrication of high-precision microfluidic and lab-on-a-chip devices. SLA photopolymers often yield parts with low mechanical compliancy in sharp contrast to elastomers such as poly(dimethyl siloxane) (PDMS). On the other hand, SLA-printable elastomers with soft mechanical properties do not fulfill the distinct requirements for a highly manufacturable resin in microfluidics (e.g., high-resolution printability, transparency, ...