Tradeoffs between energy efficiency and mechanical response in fluid flow networks

The structure of flow networks determines their function under normal conditions as well as their response to perturbative damage. Brain vasculature often experiences transient or permanent occlusions in the finest vessels, but it is not clear how these micro-clots affect the large scale blood flow or to what extent they decrease functionality. Motivated by this, we investigate how flow is rerouted after the occlusion of a single edge in networks with a hierarchy in edge cond...

In this article, we review the mathematical modeling for the vascular system.

Flow networks are essential for both living organisms and enginneered systems. These networks often present complex dynamics controlled, at least in part, by their topology. Previous works have shown that topologically complex networks interconnecting explicitly oscillatory or excitable elements can display rich emerging dynamics. Here we present a model for complex flow networks with non-linear conductance that allows for internal accumulation/depletion of volume, without an...

The prevailing theory for metabolic scaling is based on area-preserved, space-filling fractal vascular networks. However, it's known both theoretically and experimentally that animals' vascular systems obey Murray's cubic branching law. Area-preserved branching conflicts with energy minimization and hence the least-work principle. Additionally, while Kleiber's law is the dominant rule for both animals and plants, small animals are observed to follow the 2/3-power law, large a...

Fluid transport networks are important in many natural settings and engineering applications, from animal cardiovascular and respiratory systems to plant vasculature to plumbing networks and chemical plants. Understanding how network topology, connectivity, internal boundaries and other geometrical aspects affect the global flow state is a challenging problem that depends on complex fluid properties characterized by different length and time scales. The study of flow in micro...

The flow of fluids at branching junctions plays important kinematic and dynamic roles in most biological and industrial flow systems. The present paper highlights some key issues related to the flow of fluids at these junctions with special emphasis on the biological flow networks particularly blood transportation vasculature.

Allometry or the quantitative study of the relationship of body size to living organism physiology is an important area of biophysical scaling research. The West-Brown-Enquist (WBE) model of fractal branching in a vascular network explains the empirical allometric Kleiber law (the 3/4 scaling exponent for metabolic rates as a function of animal's mass). The WBE model raises a number of new questions, such as how to account for capillary phenomena more accurately and what are ...

Investigating blood flow in the cardiovascular system is crucial for assessing cardiovascular health. Computational approaches offer some non-invasive alternatives to measure blood flow dynamics. Numerical simulations based on traditional methods such as finite-element and other numerical discretizations have been extensively studied and have yielded excellent results. However, adapting these methods to real-life simulations remains a complex task. In this paper, we propose a...

Red blood cells (RBCs) play a crucial role in oxygen transport in living organisms as the vast majority of oxygen in the blood is bound to the hemoglobin molecules in their cytosol. Healthy RBCs have a biconcave shape and a flexible membrane enabling them to undergo substantial reversible elastic deformation as they traverse narrow capillaries during microcirculation. This RBC deformability is critical for efficient circulation while the unique biconcave shape of healthy RBCs...

A noteworthy aspect in blood flow modeling is the definition of the mechanical interaction between the fluid flow and the biological structure that contains it, namely the vessel wall. It has been demonstrated that the addition of a viscous contribution to the mechanical characterization of vessels brings positive results when compared to in-vivo measurements. In this context, the numerical implementation of boundary conditions able to keep memory of the viscoelastic contribu...