Universal Mortality Law, Life Expectancy and Immortality

We wish to verify that the mortality deceleration (or decrease) is a consequence of the bending of the shape parameter at old ages. This investigation is based upon the Weon model (the Weibull model with an age-dependent shape parameter) for human survival and mortality curves. According to the Weon model, we are well able to describe the mortality decrease after the mortality plateau, including the mortality deceleration. Furthermore, we are able to simply define the mathema...

Recent discoveries show steady improvements in life expectancy during modern decades. Does this support that humans continue to live longer in future? We recently put forward the maximum survival tendency, as found in survival curves of industrialized countries, which is described by extended Weibull model with age-dependent stretched exponent. The maximum survival tendency suggests that human survival dynamics may possess its intrinsic limit, beyond which survival is inevita...

Well known biological approximations are universal, i.e. invariant to transformations from one species to another. With no other experimental data, such invariance yields exact conservation (with respect to biological diversity and evolutionary history) laws. The laws predict two alternative universal ways of evolution and physiology; their singularities and bans; a new kind of rapid (compared to lifespan), reversible, and accurate adaptation, which may be directed. The laws ...

We have simulated demographic changes in the human population using the Penna microscopic model, based on the simple Monte Carlo method. The results of simulations have shown that during a few generations changes in the genetic pool of a population are negligible, while improving the methods of compensation of genetic defects or genetically determined proneness to many disorders drastically affects the average life span of organisms. Age distribution and mortality of the simu...

The analysis of the demographic transition of the past century and a half, using both empirical data and mathematical models, has rendered a wealth of well-established facts, including the dramatic increases in life expectancy. Despite these insights, such analyses have also occasionally triggered debates which spill over many disciplines, from genetics, to biology, or demography. Perhaps the hottest discussion is happening around the question of maximum human lifespan, which...

In this paper, we affirm our earlier findings of evidence for a limit to human lifespan. In particular, we assess the analyses in extreme value theory (EVT) performed by Rootz\'en and Zholud. We find that their criticisms of our work are unfounded and that their analyses are contradicted by several other papers using EVT. Furthermore, we find that even if we completely accept the conclusions about late-life human mortality reached by Rootz\'en and Zholud, their results do not...

The Gompertz law of dependence of human mortality rate on age is derived from a simple model of death as a result of the exponentially rare escape of abnormal cells from immunological response.

Trends in human longevity are puzzling, especially when considering the limits of human longevity. Partially, the conflicting assertions are based upon demographic evidence and the interpretation of survival and mortality curves using the Gompertz model and the Weibull model; these models are sometimes considered to be incomplete in describing the entire curves. In this paper a new model is proposed to take the place of the traditional models. We directly analysed the rectang...

Significant fraction (98.5% in humans) of most animal genomes is non- coding dark matter. Its largely unknown function (1-5) is related to programming (rather than to spontaneous mutations) of accurate adaptation to rapidly changing environment. Programmed adaptation to the same universal law for non-competing animals from anaerobic yeast to human is revealed in the study of their extensively quantified mortality (6-21). Adaptation of animals with removed non-coding DNA fract...

Infant deaths and old age deaths are very different. The former are mostly due to severe congenital malformations of one or a small number of specific organs. On the contrary, old age deaths are largely the outcome of a long process of deterioration which starts in the 20s and affects almost all organs. In terms of age-specific death rates, there is also a clear distinction: the infant death rate falls off with age, whereas the adult and old age death rate increases exponenti...